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Single-Isocenter Multitarget Stereotactic Radiosurgery is Associated with Less Long-Term Radionecrosis Compared with Gamma Knife for Multiple Brain Metastasis

      Radiosurgery and linear accelerator-based stereotactic radiosurgery (SRS) are both effective and offer excellent local control in the management of multiple brain metastases. When compared to conventional SRS, single-isocenter multitarget (SIMT) linear accelerator-based SRS offers superior treatment time and patient convenience, at the theoretical expense of dose conformity. To date, the clinical efficacy of SIMT and GK SRS has not been compared. We studied overall survival (OS) and radionecrosis (RN) in a multi-institutional cohort of patients treated with SIMT technique at our institution and GK at a collaborating institution.
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